Giancarlo Balercia, MD, Marco Boscaro, Lara Giovannini, MD, Francesca Paggi, MD, Giacomo Tirabassi, MD, Giorgio Panin, MD Essential Oils of Lavundula angustifolia and Tea Tree Oil Quantitatively and Qualitatively Reduce Hair Distribution in Young Women.  Endocr Rev Endocr Rev June 2012; 33

Introduction: Essential oils of Lavundula angustifolia (Lavundula officinalis) and Malaleuca alternifolia (called Tea Tree Oil) are widely used in cosmetics due to their antiseptic, anti-inflammatory and relaxing properties.Recent studies have shown that their use produces a slight estrogenic and anti-androgenic activity and contributes to a "disequilibrium" in the signaling pathway of sex hormones (1). On the basis of this evidence, we assumed that a daily topical application of these essential oils on young hypertrichotic female could reduce hair distribution of skin. Aims: to verify the consistence (diameter and length) and hair density/cm² of skin after 3 months of daily application b.i.d (on the left forearm) of oil spray containing essential oils of Lavundula angustifolia and Tea Tree Oil, compared to no application (right forearm). Methods:12 young female volunteers (mean age 31.1±4.3 years) with idiopathic hypertrichosis, not depilate for at least 6 months. They applied the oil spray (VEA Epil, Hulka S.r.l., Rovigo, Italy) b.i.d, morning and evening, on the back of the left forearm for 3 months. A self-assessment questionnaire of hair growth was given to the volunteers before and after treatment. The oil spray contained Cyclopentasiloxane, Tocopheryl Acetate, Tocopherol, Oryza Sativa/Oryza Sativa (rice) bran oil, Lavandula Angustifolia Oil, Melaleuca Alternifolia Oil. Results: after 3 months of daily treatment, the self-assessment questionnaire showed a qualitative (reduced consistency) and quantitative (hair density/cm² of skin) reduction of hair on the treated area in 80% of the studied subjects (10 women out of 12) and the efficacy continued even 3 months after treatment discontinuation. No patient had topical or systemic side effects. Conclusions: the use of essential oils of Lavundula angustifolia and Tea Tree Oil was found to be safe and effective in reducing both quantitatively and qualitatively hair distribution assuring success in its use in the cosmetic field.